Next SectionThere has been considerable debate surrounding the ethics of sham-controlled trials of procedures and interventions. Critics argue that these trials are unethical because participants assigned to the control group have no prospect of benefit from the trial, yet they are exposed to all the risks of the sham intervention. However, the placebo effect associated with sham procedures can often be substantial and has been well documented in the scientific literature. We argue that, in light of the scientific evidence supporting (...) the benefits of sham interventions for pain and Parkinson's disease that stem from the placebo effect, these sham-controlled trials should be considered as offering potential direct benefit to participants. If scientific evidence demonstrates the positive effect of placebo from sham interventions on other conditions, sham-controlled trials of interventions for the treatment of these conditions should be considered to have prospects of benefit as well. This potential benefit should be taken into account by research ethics committees in risk-benefit analyses, and be included in informed consent documents. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Where exactly should we place Adam Smith in the cannon of classical liberalism? Smith's advocacy of free market economics and defence of religious liberty in The Wealth of Nations suffice for including him somewhere in that tradition.1 The nature and extent of Smith's liberalism, however, remain up for debate. One recent trend has been to characterise Smith as a proponent of social liberalism. This includes those like Stephen Darwall, Samuel Fleischacker and Charles Griswold, who have drawn attention to a kind (...) of descriptive moral egalitarianism in Smith.2 Humans, Smith seems to hold, are naturally disposed to valuing one another under a conception of equality. But that is not all these scholars suggest. They have also hinted at something more contentious ? the idea that, according to Smith, we value one another in a way resonant with contemporary notions of human dignity, conceived as the inherent value of persons grounding certain rights to, or restrictions on, treatment by others.3 In saying so, these scholars have hit upon something remarkable. However, I also think their arguments in this respect are both indirect and incomplete. Consequently, the full import of Smith's view remains obscure. This essay aims to bring some clarity. 1I intend this historically. I grant there are good reasons to be sceptical about the ultimate fate of liberty in capitalist society (e.g. Marxist reasons and reasons based on various postmodern critiques of enlightenment ideology). Also, the designation ?free market? should be understood loosely, as most scholars now agree it is a mistake to identify Smith with thoroughgoing laissez-faire economics. 2Darwall, S., ?Sympathetic Liberalism: Recent Work on Adam Smith?, Philosophy Fleischacker, S., A Third Concept of Liberty (Princeton: Princeton University Press, 1999) and On Adam Smith's Wealth of Nations (Princeton: Princeton University Press, 2004); and Griswold, C., Adam Smith and the Virtues of Enlightenment (New York: Cambridge University Press, 1999). Other major commentators holding some version of this view might include Raphael, D. D. The Impartial Spectator (New York: Oxford University Press, 2007) and Vivienne Brown, Adam Smith's Discourse: Canonicity, Commerce and Conscience (London: Routledge, 1994). 3See e.g. Fleischacker (2004), 205; Darwall at 142, 156 and Griswold at 235?239. However, one must read Fleischacker carefully, for he also uses the adjectival ?dignified? to express Smith's concern with what is ?honourable? or ?respectable? about persons, which use does not obviously match up with the notion of inherent value (see e.g. p. 207). Darwall's argument includes by far the most explicit discussion of ?dignity? as I've defined it. But as Darwall's article is ostensibly a book review (albeit a substantive one that addresses three books at once, including Griswold's), it cannot be called a direct inquiry. Griswold never explicitly puts his interpretation in terms of ?dignity?, but that is clearly what he is after. Thus Darwall also reads him that way. (shrink)

Cet essai se situe sur le terrain de la théologie pour relever l’usage qu’elle en fait comme clef du langage sur Dieu. A ce titre, l’analogie déborde et dépasse le domaine de la logique et de l’épistémologie pour servir une pensée non seulement spéculative, mais encore spirituelle et mystique. Son emploi en théologie traduit l’aspect intellectuel d’une attitude d’abord existentielle et croyante où l’homme se reconnaît comme créature distante de son Créateur, mais surtout en tant que nature raisonnable, comme fait (...) à l’image de Dieu et appelé à la dignité de fils du Dieu Père. La réflexion sur l’analogie nous introduit ainsi inévitablement dans le domaine de l’image dont l’homme ne porte la marque qu’en raison de sa participation à l’image parfaite de Dieu qu’est son Verbe. Si l’analogie suggère la distance entre les termes transcendant et immanent qu’elle relie, ne reviendrait-il pas à l’image d’effectuer leur rapprochement ? S’appuyant sur la théologie de S. Thomas, l’enquête de G. Rémy traite de l’analogie comme outil conceptuel indispensable au discours sur Dieu et le mystère trinitaire ; le relais sera pris par la notion d’image appliquée à l’homme mais dont l’archétype est le Christ.This essay is situated in the area of theology to note how analogy is used as a key to language about God. As such, analogy goes beyond and transcends the domain of logic and epistemology to serve not only speculative but even spiritual and mystical reflection. Its use in theology translates the intellectual aspect of an attitude at first existential and believing, in which man recognizes himself as a creature distant from his Creator, but, above all, as a reasonable nature made in the image of God and called to dignity as the son of God the Father. This reflection on analogy inevitably leads us into the domain of the image, of which man carries only the mark by reason of his participation to the perfect image of God who is his Word. If analogy suggests the distance between the transcendent and immanent terms that it connects, is it not the role of the image to bring them close to each other? Relying on the theology of St. Thomas, the inquiry of G. Remy treats analogy as a conceptual tool that is indispensable to the discourse on God and the Trinitarian mystery. It is relayed by the notion of image applied to man, of which the archetype is Christ. (shrink)

On the God of the Christians tries to explain how Christians conceive of the God whom they worship. No proof for His existence is offered, but simply a description of the Christian image of God. The first step consists in doing away with some commonly held opinions that put them together with the other "monotheists," "religions of the book," and "religions of Abraham." Christians do believe in one God, but they do not conceive of its being one in the same (...) way as other "monotheists," like the first of them, the pharaoh Akhenaton (18th century before J.C.), like some philosophers, e.g., Aristotle, or like Islam. Christians admit the authority of a Holy Book, but don't consider it as being the peak of God's revelation. For them, revelation culminates in the person, life, and doings of Jesus - including his passion and resurrection. Christians acknowledge the exemplary figure of Abraham, but the stories they tell about him they share with Jews, but not with Muslims, who see in him the first Muslim. The Trinity is not a way to loosen the exclusivity of the only God. It is the very way in which God is one, i.e., in the inner richness and fecundity of love. The God of the Christians is Father, but not male. Human males become fathers through the mediation of a female. God is so radically the Father of everything and, in a very special sense, of the eternal Son, that He is not in need of a partner. His fatherhood can in no way legitimate the superiority of the male over the female sex. The God of the Christians doesn't want us to obey Him in order to enslave us; He expects us to act freely according to what is good for us. Now, the Good is not something that He has in store and bestows on His creatures. The Good is what He is and He is the Good of His creatures. The God of the Christians is merciful, but He takes seriously man's freedom, even when man doesn't accept Him. Hence, He doesn't content Himself with forgiving fromthe outside. He has to contrive a system (technically speaking: salvation history or "economy of salvation") that will enable Man freely to accept His love. (shrink)

The French school of theoretical biology has been mainly initiated in Poitiers during the sixties by scientists like J. Besson, G. Bouligand, P. Gavaudan, M. P. Schützenberger and R. Thom, launching many new research domains on the fractal dimension, the combinatorial properties of the genetic code and related amino-acids as well as on the genetic regulation of the biological processes. Presently, the biological science knows that RNA molecules are often involved in the regulation of complex genetic networks as effectors, e.g., (...) activators, inhibitors or hybrids. Examples of such networks will be given showing that there exist RNA “relics” that have played an important role during evolution and have survived in many genomes, whose probability distribution of their sub-sequences is quantified by the Shannon entropy, and the robustness of the dynamics of the networks they regulate can be characterized by the Kolmogorov–Sinaï dynamic entropy and attractor entropy. (shrink)

To what extent can an agent be held responsible for what he does? According to Aristotle, we are answerable for our voluntary actions, the “voluntary” being “[1] that of which the origin is in oneself, [2] when one knows the particular factors that constitute the location of action.” This question, which was of paramount importance for Anscombe, led her to focus on the second, epistemic condition of responsibility. This chapter suggests that in fact, a large part of her philosophy of (...) action can be read as an effort to build a complex and subtle answer to the question what kind of knowledge an agent must have of his own action in order for him to be accountable for it (and/or for all or some of its consequences). In Intention, Anscombe shows that for his action to be intentional under some description, an agent must have a practical knowledge of it under this very description; that is why ignorance can sometimes be put forward as a ground for exoneration. But ignorance can also be blameworthy, when the agent could and should have known what he is ignorant of. Elucidating the possibility of voluntary ignorance brings into light a fundamental obligation to know which takes its meaning from, and has its roots in, Anscombe’s Thomist background. (shrink)

ABSTRACTThis study investigates the effects of emotion on the integration mechanism which binds together the components of an event and the relations between these components and encodes them within a memory trace [Versace, R., Vallet, G. T., Riou, B., Lesourd, M., Labeye, É, & Brunel, L.. Act-In: An integrated view of memory mechanisms. Journal of Cognitive Psychology, 26, 280–306. doi:10.1080/20445911.2014.892113]. Based on the literature, the authors argue that, in a memory task, contextual emotion could strengthen the integration mechanism and, more (...) specifically, the relations between a target item and its contextual features. To test this hypothesis, the authors used two odorants to compare the effects of a negative context with those of a neutral one on three different types of recall: item recall, source recall and recall of the association between an item and its location. The results show... (shrink)

This volume presents a penetrating interview and sixteen essays that explore key intersections of medieval religion and philosophy. With characteristic erudition and insight, Rémi_ _Brague focuses less on individual Christian, Jewish, and Muslim thinkers than on their relationships with one another. Their disparate philosophical worlds, Brague shows, were grounded in different models of revelation that engendered divergent interpretations of the ancient Greek sources they held in common. So, despite striking similarities in their solutions for the philosophical problems they all faced, (...) intellectuals in each theological tradition often viewed the others’ ideas with skepticism, if not disdain. Brague’s portrayal of this misunderstood age brings to life not only its philosophical and theological nuances, but also lessons for our own time. (shrink)